已有一些研究表明低维生素D水平可能与心血管疾病相关,这种相关性产生的机制是什么?会受到哪些因素影响?这种关系在不同人种之间的差异是什么?就这些问题《国际循环》记者对Dr Erin Michos (The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore) 进行了专访。
<International Circulation>: Is there any similar relationship specific to the Asian population?
《国际循环》:这在亚洲人群中有哪些相似的关系吗?
Dr Michos: People with lighter skin pigmentation may be able to make more vitamin D when exposed to adequate UVB exposure. It depends in which part of the world they live,the degree of UVB exposure and whether sunscreen is used. I am surprised, for example, in places like the Caribbean where they get ample sunlight exposure, people wear sunscreen and work indoors and do not get enough vitamin D. Even in parts of the world where there is adequate sunlight exposure, many factors like smog and pollution prevent the UVB-generation of vitamin D. In NHANES, the Asian population was a small minority and we didn’t look at them specifically, but it is a problem worldwide and in the Eastern part of the world there is a lot of vitamin D insufficiency.
Dr Michos: 皮肤中色素少的人暴露于足量的UVB之下可能产生更多的维生素D。这取决于他们居住于世界的哪个地方,以及UVB的暴露率和是否使用防晒霜。我很惊奇,比如在人们能获得充足的阳光照射的地方像加勒比海,人们涂抹防晒霜并在室内工作,在中东,覆盖全身的着装方式,即使是在世界上能获得足够阳光照射的地方,很多因素比如烟雾和大气污染都会阻止UVB产生维生素D。在NHANES研究中,亚洲人群所占的比例很小,因此我们并没有特别地对这一人群进行分析,但是维生素D不足是全世界范围内的一个问题,并且即使在西方国家也是如此。